不同类型正常乳腺表观扩散系数值差异的研究
蔡世峰 赵斌 王光彬 于台飞
【摘要】 目的 研究不同类型正常乳腺表观扩散系数( ADC) 值的差异, 探讨ADC 值与组织学
分型之间的关系。方法 采用单次激发平面回波( EPI) 技术, 扩散敏感因子( b) 值分别为0、500、
1000 s /mm2 , 对62 个正常乳腺( 包括42 例乳腺病变患者的对侧正常乳腺及10 名健康志愿者20 个乳
腺) 进行MR 扫描及MR 扩散加权成像( DWI) 检查, 计算62 个正常乳腺分别在不同b 值时的ADC
值。将62 个正常乳腺分为3 型, 比较3 型之间ADC 值的差异及不同b 值时ADC 值的差异。结果
42 例乳腺病变患者对侧正常乳腺的DWI 及ADC 图与组织切片对比, 不同类型乳腺组织学结构不同,
其DWI 及ADC 图表现亦有差异。62 个正常乳腺分为致密型10 个, 分叶斑点型42 个及退化型10 个。
致密型和分叶斑点型乳腺随b 值降低ADC 值升高, 而退化型乳腺随b 值降低ADC 值变化不明显。
b = 1000 ～0 s /mm2 时, 致密型、分叶斑点型、退化型乳腺ADC 值分别为( 1. 70 ±0. 37) 、( 1. 93 ±0. 46) 、
( 1. 18 ±0. 65) × 10 - 3 mm2 /s , 3 组间比较差异有统计学意义( F = 12. 998, P = 0. 000) 。不同b 值时每
2 种类型间进行单因素方差分析, 致密型和分叶斑点型之间差异无统计学意义( F = 2. 167, P =
0. 147) ; 致密型和退化型之间、分叶斑点型和退化型之间差异均有统计学意义( F 值分别为5. 593、
19. 128, P 值分别为0. 029、0. 000) 。结论 3 型正常乳腺ADC 值受乳腺组织学结构的影响, 致密型和
分叶斑点型乳腺ADC 值受b 值高低的影响。
【关键词】 乳房; 磁共振成像; 图像处理, 计算机辅助
Study of appa rent diffusion coefficient va lue in t he norma l br east CAI Shi-feng* , ZHAO Bin,
WANG Guang-bin, YU Tai-fei. * The Medical Imaging Center of Linyi People′s Hospita l of Linyi City,
Shandong Province, Linyi 276003, China
【Abst ract】 Objective To investigate the differences of apparent diffusion coefficient ( ADC) value
in normal breasts and to evaluate the correlation between ADC value and corresponding histology. Methods
Sixty-two normal breasts including 42 normal breasts of 42 patients with unilateral lesions and 20 normal
breasts of 10 volunteers were studied. The ADC value of all 62 normal breasts were calculated when b value
was given from 1000 to 0 s /mm2 , 1000 to 500 s /mm2 and 500 to 0 s /mm2 . The MRI features of 60 normal
breasts were classified into 3 types ( dense, lobular-speckled, degenerative types ) according to Wolf′s
classification and histology. Results DWI and ADC images were different in 3 types of normal breasts
because of different histologic structures. The mean ADC value of the dense type breasts was ( 1. 70 ±
0. 37)× 10 - 3mm2 / s, the lobular-speckled type was ( 1. 93 ±0. 46)× 10 - 3mm2 / s and the degenerative type
was ( 1. 18 ±0. 65)× 10 - 3mm2 / s ( F = 12. 998, P = 0. 000) . There were no significant differences between
the dense type and the lobular-speckled type ( F = 2. 167, P = 0. 147) , but significant differences between
the dense type and the degenerative type, the lobular-speckled type and the degenerate type ( F = 5. 593 and
19. 128; P = 0. 029 and 0. 000) . When b value decreased, the ADC value of the dense type and the lobularspeckled
type increased correspondingly, but the degenerative type didn′t increase apparently. Conclusion
ADC value was influenced by histologic structures in normal breasts and also was influenced by b value in the
dense type and lobular-speckled type breasts.
【Key wor ds】 Breast; Magnetic resonance imaging; Image processing, computer-assisted

不同类型正常乳腺表观扩散系数值差异的研究--乳腺.rar