Adlyfe公司研制出疯牛病的早期血液学检测方法

一种敏感的血液学检测用于折叠蛋白疾病，例如牛海绵体脑病，又叫做疯牛病，能够提供早期诊断。

这种检测使用小型的、模拟蛋白折叠的合成肽类。这些肽类检测方法能够在有害蛋白质在大脑蓄积之前，检测出血液中的蛋白。这些有害蛋白质的蓄积与大脑损伤、疾病症状盒最终的死亡有关联。

这种检测方法是由Cindy Orser医生研制的，他是Adlyfe公司的研究与开发副总裁。这种检测方法设计用于检测绵羊疯痒病和人类Cruetzfeld-Jacob病也就是疯牛病。该公司对该项技术拥有11项，该技术同样可以用于其他蛋白折叠疾病例如Alzheimer病和Huntington病。Adlyfe公司已经在牛、绵羊和人类的临床实验室采集的大脑组织和血液样本中检测出了蛋白感染素疾病。

Adlyfe公司首席执行官Alan S. Rudolph评论说：“我们对测试的早期结果感到十分鼓舞，这标志着我们能够从动物和人类的血液和组织样本中成功检测出疾病。我们希望能够为这些恶性疾病的早期检测和诊断提供新的检测方法。”Adlyfe是一家生物科技公司，侧重于新型血液诊断和治疗领域。

Blood Test for Mad Cow Disease
 
A sensitive blood test for protein-folding diseases such as spongiform bovine encephalopathy (SBE), also known as mad cow disease, could provide an earlier diagnosis.

The test uses small, synthetic peptides that mimic protein folding. The peptides detect the build-up of damaging proteins in blood before they accumulate in the brain. This accumulation is correlated to brain damage, disease symptoms, and eventual death.

The test was developed by Dr. Cindy Orser, vice president, research and development, Adlyfe, Inc. (Rockville, MD, USA). The test is designed to detect sheep scrapie and Cruetzfeld-Jacob disease in humans as well as mad cow disease. The company has 11 patents pending on the technology, which also addresses other protein-folding diseases such as Alzheimer’s and Huntington’s disease. Adlyfe has demonstrated detection of prion diseases in brain tissue and the blood of cattle, sheep, and humans in clinical laboratory sampling.

“We are very encouraged by the early results of our test which show we can detect disease in blood and tissue samples from animals and humans,” commented Alan S. Rudolph, CEO of Adlyfe. “We look forward to offering a new test for early detection and diagnosis of these debilitating diseases.” Adlyfe is a biotechnology company focused on novel blood diagnostics and therapeutics.