Ventria公司推出植物来源的细胞培养基

一种用于细胞培养的新型植物来源的重组生长因子，将会提升产量和安全性。

该产品被称为Lacromin，是一种来源于植物的重组人乳铁蛋白，这种因子要优于通常使用的动物来源生长因子转铁蛋白。Lacromin是Ventria生物科学公司的产品。

Lacromin是一种强大的生长因子，能够促进许多细胞株的生长，包括中国地鼠卵巢细胞和小鼠杂交瘤细胞。它还能够提高细胞密度，与转铁蛋白相比，能够较少细胞增殖一倍的时间。因为Lacromin来自植物，所以没有任何病毒和或者朊病毒污染的危险。在杂交瘤细胞株中，与使用转铁蛋白相比，Lacromin能够将IgG产量增加50％，与胎牛血清相比，增加6％。

“我们对Lacromin的这些结果感到十分鼓舞。”Ventria生物科学公司研究与开发部副总裁Ning Huang如此评论。Huang先生2005年7月在堪萨斯市举行的“哺乳动物细胞培养产品原材料和一次性处理系统大会”上介绍了Lacromin。“在今天的会议上，我报道的结果显示：与动物来源的转铁蛋白相比较，Lacromin能够显著增加抗体的产量。”

该公司将会把Lacromin推介给那些寻求无血清和无动物成分的细胞培养基的公司。
 
Plant-Derived Culture Media
 
A new plant-derived recombinant growth factor for cell culture media promotes productivity and safety.

Called Lacromin, the growth factor is a recombinant human lactoferrin derived from plants, which outperforms transferrin, a common animal-derived growth factor. Lacromin is the product of Ventria Bioscience (Sacramento, CA, USA).

Lacromin is a strong growth factor that has promoted cell growth in many cell lines, including Chinese hamster ovary (CHO) cells and mouse hybridoma cells. The growth factor also promotes higher cell density and reduces cell doubling time when compared to transferrin. Since Lacromin is derived from plants, it is free of any viral or prion containment risks. In hybriderma cells, Lacromin increased IgG productivity by 50% compared to transferrin and by 6% compared to fetal bovine serum (FBS).

“We are very encouraged by the positive results we have generated on Lacromin,” said Ning Huang, vice president of research and development, Ventria Bioscience. Mr. Huang introduced Lacromin at the Raw Materials and Disposable Process Systems for Mammalian Cell Culture Products Conference in Kansas City (MO, USA) in July 2005. “At the conference today, I presented results showing Lacromin significantly increased the productivity of antibody production when compared with animal-derived transferrin.”

The company will market Lacromin to companies seeking a serum-free and animal component-free cell culture media source.