意大利研究人员发现影响LAGB治疗肥胖症的遗传因素

 
一项研究发现，遗传因素在体重的调节和维持中发挥作用，还可能在确定患者对腹腔镜调节胃部粘合手术(LAGB)的反应。

迄今为止，医生还不知道影响患者对LAGB治疗反应的基因因素，该治疗是一种治疗肥胖症的外科手术，用于限制胃上部的膨胀容积，从而制造一种较小的胃袋，限制进食并产生饱腹感。

研究人员评估了近期接受LAGB治疗的167例肥胖患者的成功之处。每例患者都接受特定基因变异、或者单个核苷的多态性，从而确定接受这种外科手术治疗患者体重减轻的因素。在随访6个月之后，G-174G IL6基因型受试者比G-174C或者C-174G基因型受试者体重下降的更多，A-866A UCP2基因型比G-866G或者G-866A基因型体重下降更多。这些结果显示，遗传因素确实影响体重的调节和维持。

来自意大利Catanzaro的Magna-Graecia大学临床与实验医学系的研究人员认为，基因或许在影响患者对LAGB治疗反应中发挥作用。在2005年9月《临床内分泌与代谢期刊》上报道他们的研究结果。
 
Genetic Impact on Gastro Surgery
 
A study has found that genetics play a role in the regulation and maintenance of body weight and may also help determine a patient’s response to laparoscopic adjustable gastric binding (LAGB).

Until now, doctors have not known whether genetic factors affected a patient’s response to LAGB, a type of surgery for obesity that entails placing an inflatable band around the upper stomach to create a small gastric pouch that limits food consumption and creates a feeling of fullness.

Researchers evaluated the success of 167 morbidly obese patients who had recently undergone LAGB. Each was evaluated for specific genetic variants, or single nucleotide polymorphisms, to see how each affected weight loss following this type of surgery. After six months of follow-up, subjects with a G-174G IL6 genotype lost more weight than subjects with a G-174C or C-174G genotype, while subjects with an A-866A UCP2 genotype lost more weight than subjects with a G-866G or G-866A genotype. The findings show that genetics do influence the regulation and maintenance of body weight.

The researchers, from the department of clinical and experimental medicine, University of Magna-Graecia in Catanzaro (Italy), suggest that genes may also play a role in the success of a subject’s response to LAGB. Their findings were reported in the September 2005 issue of The Journal of Clinical Endocrinology & Metabolism.