美国加州大学发现诊断狼疮的生物指标

 
研究人员在一项新研究中发现了一种被称为“好胆固醇”的高密度脂蛋白(HDL)，能够促发系统性红斑狼疮（SLE）和风湿性关节炎患者动脉粥样硬化症和心脏疾病的发生。

这种新型HDL叫做亲炎症性高密度脂蛋白(piHDL)。在研究中研究人员测定了来自154例女性SLE患者、73例年龄匹配的对照、50例风湿性关节炎患者的piHDL。SLE患者的HDL中piHDL水平显著高于对照组。同样在10例确诊为动脉粥样硬化症的患者发现了piHDL。这种生物指标在12例发生脑卒中的SLE患者中的6例同样升高。

这样研究是由美国加利福尼亚大学洛杉矶分校(UCLA, USA)David Geffen医学院的Hahn医生及其同时主持完成的。

Potential Biomarker for Lupus
 
Investigators in a new study have uncovered a form of high-density lipoprotein (HDL), known as the “good cholesterol,” which promotes atherosclerosis and heart disease in many people with systemic lupus erythematosus (SLE) and rheumatoid arthritis.

This new form of HDL is called pro-inflammatory (piHDL). In the study, researchers measured the presence of piHDL in samples of blood plasma from 154 women with SLE, 73 age-matched controls, and 50 women with rheumatoid arthritis. The HDL of those with SLE contained significantly more piHDL than the control group. Aslo, piHDL was found in eight of the 10 individuals with SLE determined to have atherosclerosis. The biomarker was similarly high in half of the 12 subjects with SLE who had suffered a stroke.

The study was conducted by Dr. Hahn and colleagues at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA, USA).