Mayo发现心房容积预测心血管事件

 
一项新研究显示，左房容积(LAV)测定是一种很有前途的有效的评估检测房颤(AF)患者工具。

在这项研究中，Mayo诊所(Rochester, MN, USA)的科研人员对46例患房颤的患者进行了长期(中位数时间：27年)的随访。 23例患者(50%)经历过心血管事件。在7例患者中发生了脑梗塞，11例发生心肌梗塞，16例出现充血性心脏衰竭。

为了探讨为什么良性AF会进展至风险相关的AF，Mayo研究小组测定了LAV的变化。无并发症的AF患者心房体积正常，并在数十年内保持不变，风险极低。只有在心房变大后，心房压显著增加，开始出现脑卒中和心脏衰竭。

在多变量分析中，患者的LAV指数是32ml/m2或者更大，无事件生存率显著恶化。所有这些患者都出现了脑梗塞。这些研究结果发表在2005年12月《欧洲心脏期刊》。

 
 
Atrial Volume Predicts Cardiovascular Events
 
Left atrial volume (LAV) measurement is a promising and powerful tool for the evaluation and monitoring of patients with atrial fibrillation (AF), a new study suggests.

In this study, scientists at the Mayo Clinic (Rochester, MN, USA) conducted a long-range (median of 27 years) follow-up of 46 patients with lone AF. Twenty-three of the patients (50%) experienced cardiovascular events. Cerebral infarction occurred in seven patients, myocardial infarction occurred in 11, and congestive heart failure in 16.

In an attempt to find out why a benign lone AF may evolve into a risk-associated AF, the Mayo group measured the changes in LAV. Patients with ‘uncomplicated’ lone AF had normal atrial size, which remained unchanged for decades, signifying very low risk. Only when the atria became large, signifying increased atrial pressure, did stroke and heart failure begin to occur.

In a multivariate analysis, patients with an LAV index of 32 ml/m2 or greater had a significantly worse event-free survival. All the cerebral infarctions occurred in these patients. The results were published in the December 2005 edition of the European Heart Journal.