Oncolytics开发清除癌细胞的病毒药物

 
 
一种常见肠道病毒能够清除自身移植干细胞化疗之后的癌症细胞。

一种新型药物包含人类呼吸道肠道孤儿病毒(reovirus)，叫做Reolysin，被设计用于清除自身干细胞移植物中的癌症细胞，这些癌细胞会在高剂量化疗之后重新出现。当进入血液之中的时候，能够在其中复制，并最终杀死它们。这种reovirus病毒在癌细胞内复制，从而激活Ras信号途径，这是一种常见的突变，在大约三分之二的人类肿瘤中存在。Oncolytics生物科技公司(Calgary, Canada)研制开发了Reolysin。

Virus Purges Cancer Cells in Stem Cell Transplants
 
A common enteric virus may be able to eliminate cancer cells from autologous stem cell transplants following chemotherapy.

A new proprietary formulation of the human respiratory enteric orphan virus (reovirus) called Reolysin is designed to purge cancer cells from autologous stem cell transplants that are reintroduced to the body following high-dose chemotherapy. When introduced into the blood, the reovirus enters cancer cells,replicates within them, and ultimately kills them. The reovirus works by replicating within cancer cells that have an activated Ras pathway, a common mutation that is shared by approximately two-thirds of all human cancers. Reolysin was developed by Oncolytics Biotech (Calgary, Canada).