BioMosaics生产出检测肝癌的单克隆抗体

 
一种单克隆抗体能够帮助鉴别人组织和血清中的glypican-3 (GPC3)。GPC3的表达是原发性肝癌的一个指标。

GPC3属于糖基磷脂酰肌醇-锚定细胞表面硫酸乙酰肝素蛋白多糖家族。1G12单克隆抗体已经被用于恶性和非恶性肝脏组织中检测GPC3表达，以及检测血清中ELISA检测GPC3。通过免疫组化检测发现在蛋白水平，大多数原发性肝癌表达GPC3，包括小肝癌，但是在正常肝脏和良性肝脏病变检测不出。在大部分原发性肝癌患者血清中GPC3水平显著升高。这种单克隆抗体是BioMosaics公司(Burlington, VT, USA)的产品。
 
Monoclonal Antibody Helps Detect Liver Cancer
 
A monocloncal antibody is being used to aid the identification of glypican-3 (GPC3) in human tissues and serum. GPC3 expression is an indication of primary liver cancer.

GPC3 is a member of the glypican family of glycosyl phosphatidylinositol-anchored cell-surface heparan sulfate proteoglycans. The 1G12 monoclonal antibody has been used to assess GPC3 expression in malignant and non-malignant liver tissue samples and for enzyme-linked immunosorbant assay (ELISA) detection of GPC3 in the serum. GPC3 is expressed at the protein level by immunohistochemistry in most cases of primary liver cancer including small tumors, but is undetectable in normal liver and benign hepatic lesions. GPC3 is significantly elevated in the serum of a large proportion of patients with primary liver cancer. The monoclonal antibody product was developed by BioMosaics (Burlington, VT, USA).