加速治疗恶性高热的新方法

加速治疗恶性高热的新方法
     由于有了一种对用来调配丹曲洛林纳（肌松药）的稀释剂的新的加温方法，静脉注射解救麻醉后恶性高热的救命药丹曲洛林纳能够起效更快。
      MH（恶性高热）是一种静息的、获得性的肌肉代谢紊乱，触发于吸入性麻醉或是注射琥珀胆碱麻醉后导致的高体温。这项研究的目的确定一种更合适的加热稀释液的方法的可行性，加热稀释液的目的是为了将之于DS （丹曲洛林纳）混合，从而为解救MH 的发作赢得宝贵的时间，并给药解救。
      这项研究由Kevin Baker，他是位于温哥华里齐蒙得（Richmond）街伦敦西区麻醉属玛丽医院的麻醉护士以及其同事一起实施的。研究者发现通过加热DS 稀释液（无菌水）到41℃ 能安全的加快混合时间并快速解救MH 省去30秒或者更长的时间的DS准备过程（正常需要2分钟），为了实施研究，在全国的医院病房四周使用了两种标准的流体加热器。研究员会员Donna Landriscina———认定的注册麻醉护士（CRNA）说：“每秒钟我们就能治疗一位病人”，这一研究表明，快速DS给药是可能的，籍此，增加病人成功获救的机会。
      诊断一个病人MH后要求在旁的施麻醉者快速反应。Kevin Baker说：“过去一线麻醉护士已经极大的提高了麻醉的安全性，未来几十年，这一新的发现会进一步是患者受益。”
      来源于：美国麻醉护士协会American Association of Nurse Anesthetists (AANA)

Malignant Hyperthermia: New Way to Speed Up Treatment
The intravenous administration of life-saving dantrolene sodium to anaesthesia patients with malignant hyperthermia

can occur significantly faster thanks to a new method of warming the diluent that is used to prepare the antrolene

sodium for use.
Malignant hyperthermia (MH) is a silent, inherited metabolic disorder of the muscle that is triggered by specific

inhaled anaesthetics or succinylcholine and can result in a severely high body temperature. The study set out to

determine the possibility of a more expedient method of warming the diluent in order to mix it with dantrolene

sodium (DS), thus saving precious time between the onset of MH and the administration of DS.

The study was conducted by Kevin Baker, staff nurse anaesthetist for West End Anesthesia Group at St. Mary’s

Hospital in Richmond and colleagues. The researchers discovered that by warming the DS diluent (sterile water) to 41

degrees Celsius it safely lessoned the mixing time and resulted in faster treatment of patients suffering from MH.

Thirty seconds or more could be shaved off the DS preparation process, which normally takes two minutes. To conduct

the study, two standard fluid warmers were used that are typically found in hospital rooms around the country.

“Every second counts when treating a patient with malignant hyperthermia,” said research associate Donna

Landriscina, Certified Registered Nurse Anesthetist (CRNA). “This research indicates that it is possible to

administer DS faster, thereby increasing the patient’s chances of a successful outcome.”

The diagnosis of malignant hyperthermia in a patient requires swift action on the part of the anaesthesia provider.

“For years, nurse anaesthetists have been on the forefront of research that has greatly enhanced anaesthesia

safety,” said Kevin Baker. “New discoveries of best practices such as this one will benefit patients for decades

to come.”

MEDICA.de; Source: American Association of Nurse Anesthetists (AANA)