PreAnalytix公司研制出新型血液RNA处理系统

一种新型血液RNA系统用于收集、存储、运输血液，在密闭的试管中稳定细胞内RNA，以及后续的从全血中分离纯化细胞内RNA用于进行分子诊断的逆转录PCR检测。

PaxGene系统是由PreAnalytix GmbH公司 (Hombrechtikon, Switzerland)研制开发的。该系统已经获得了美国食品药品管理局的许可并获得了GE商标，同时PreAnalytix得到了ISO 9001证书。

PaxGene血液RNA系统整合了全血收集、核酸稳定以及RNA纯化的关键步骤。通过将与RNA处理相关的不可预测性降低至最低，该系统提高了细胞内RNA检测的准确性以及效率，并降低了成本。PaxGene系统包括血液收集管以及核酸处理试剂盒。收集试管包括了一种能够使细胞内RNA在室温条件下稳定3天、-20C条件下稳定6个月的试剂。

Targeted诊断与治疗公司的首席执行官Daniel J.O’Shannessy博士说：“PaxGene血液RNA系统能够显著提高检测信使RNA的能力。PaxGene系统提供的RNA稳定性允许我们位于宾夕法尼亚州的实验室，从美国以及世界范围内接受血液样本。”

Novel Blood RNA System
 
A new blood RNA system is for the collection, storage, transport of blood, the stabilization of intracellular RNA in a closed tube, and the subsequent isolation and purification of intracellular RNA from whole blood for reverse transcription polymerase chain reaction (RT-PCR) used in molecular diagnostic testing.

The PaxGene system was developed by PreAnalytix GmbH (Hombrechtikon, Switzerland). The system has been cleared by the U.S. Food and Drug Administration (FDA) and has received the CE Mark, while PreAnalytix has received ISO 9001 certification.

The PaxGene blood RNA system is an enabling technology that consolidates and integrates the key steps of whole blood collection, nucleic acid stabilization, and RNA purification. By minimizing the unpredictability associated with RNA processing, the system provides enhanced accuracy, greater efficiencies, and reduced costs of intracellular RNA analysis. Intracellular RNA is a key component of numerous diagnostic products. The PaxGene system comprises a blood collection tube and a nucleic acid processing kit. The collection tube contains a reagent that stabilizes intracellular RNA for three days at room temperature and up to six months at -20oC.

“The PaxGene Blood RNA system has significantly enhanced our ability to detect messenger RNA,” observed Daniel J. O’Shannessy, Ph.D., COO of Targeted Diagnostics & Therapeutics, Inc. (West Chester, PA, USA). “The stability of the RNA afforded by the PaxGene system allows us to received blood samples from across the United States and internationally into our laboratory in Pennsylvania.”