染色体不稳定性能够预测癌症的预后

 
科研人员发现基因芯片谱能够提示染色体的不稳定性，这种不稳定性能够进一步发展成为染色体异常，在各种癌症中都可以预示临床转归。

在2006年8月《自然遗传学》在线版的一项研究报道说，染色体异常的检测提供了确定各种肿瘤恶性程度的途径。对18项先前癌症研究中基因表达（活性）资料的研究，代表了6种癌症类型，科研人员发现这种基因谱，或者特性，能够预测出12个研究人群的预后很差。
 
Chromosome Instability Predicts Cancer Outcome
 
Scientists have found that a gene-chip profile indicating chromosome instability--an increased tendency to develop chromosome aberrations--predicts clinical outcome in a broad range of cancers.

A study appearing in the August 2006 online journal Nature Genetics reported that chromosomal aberrations provide a way to determine the malignant potential of cancer over a broad range of tumors. Using data on gene expression (activity) from 18 previous studies of cancer, representing six cancer types, the scientists found that this genetic profile, or signature, predicted poor clinical outcome in 12 of the populations studied.