ParAllele公司推出检测SNPs的新产品

一种具有20000种非同义单核苷酸多态性（SNPs）的检测面板现在可以用于人类基因分型的研究。

这种检测面板由美国ParAllele基因分型服务公司提供，以前只有10000种SNPs。这次扩大的编码SNP面板代表了能够编码氨基酸变化的SNPs基因，而据信这对基因型会产生最大的影响。这种面板是使用了该公司的分子倒位探针来研制开发的，将产生高水平多元化改变，而这对基因分型是必不可少的。这种最新面板还包括那些从ParAllele中经过筛选的超过25000种以前未经证实的SNPs。最终的经过选择的扩大SNP面板，能够从3个种族人群超过8百万基因型的300个个体进行基因分型。

ParAllele的研究主任、共同创始人Malek Farhem博士说：“这种扩大至20000种完全证实的非同义SNPs，不仅是一种符合成本/效益比的途径，能够进行完整的基因分析，而且具有具有极高的决定性意义，因为我们选择用于这种测试面板的SNPs是那些与功能性反应最相关的。”

该公司的产品与服务使用那些具有决定性意义生化过程的多元化途径，而不是复杂的设备去发现分析的人类基因组变化。
 
Increased Assay Panel of SNPs
 
An assay panel with 20,000 non-synonymous single nucleotide polymorphisms (SNPs) is now available for use in human genotyping studies.

The assay panel, from ParAllele Genotyping Services (So. San Francisco, CA, USA), formerly had only 10,000 SNPs. This enlarged coding SNP panel represents genes with SNPs that code for amino acid changes, which are those believed to have the biggest impact on phenotype. The panel was developed by using the company’s molecular inversion probes, which result in extremely high levels of multiplexing, essential for genotyping demands. This latest panel also includes some of those selected by ParAllele from > 25,000 previously unvalidated SNPS. The final SNP panel selection for the enlarged panel was achieved by genotyping around 300 individuals from three ethnic populations accounting for > 8 million genotypes.

“This panel enlarged to 20,000 fully validated non-synonymous SNPs not only represents a cost-effective way of achieving whole genome analysis but has the potential of an extremely high payoff, since the SNPs that we have selected for this assay panel represent those most likely to be associated with a functional response,” said Malek Farhem, M.D., Ph.D., co-founder and director of research at ParAllele.

The company’s products and services utilize a multiplexed approach that leverages novel biochemical processes rather than complex instrumentation to discover and analyze minute variations in the human genome.