运动可能对心率不齐患者危害极大

 
一项小鼠研究为下述问题提供了一个可能的解释：为什么人缺乏心肌肌集钙蛋白心跳不规则，为什么只会在运动而不是其他时候发生死亡。

拟正交感神经素多态心室心动过速(CPVT)是一种危及生命的疾病，其特征是在运动时不规则心跳。CPVT可能是由编码CASQ2的基因发生突变引起的，这是一种Ca2+结合蛋白，在心脏肌细胞中储存Ca2+。尽管CASQ2被认为在调节心脏收缩方面具有重要作用，而缺乏CASQ2以及心脏收缩相对正常的人都已经被鉴别出来。
 
Exercise May Be Deadly for Arrhythmia Patients
 
A new study in mice has provided a potential explanation for why the heartbeat of humans lacking the protein cardiac calsequestrin (CASQ2) is irregular and potentially fatal only during exercise and not at other times.

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a life-threatening disease characterized by an irregular heartbeat during exercise. CPVT can be caused by mutations in the gene encoding CASQ2, a Ca2+ binding protein found in the Ca2+ storage facility of the muscle cells of the heart. Paradoxically, although CASQ2 is thought to have a crucial role in regulating contraction of the heart, individuals lacking both copies of CASQ2 and whose hearts contract relatively normally have been identified.