NYU发现脑部手术能够降低癫痫发作频率

 
根据一项最新研究，一种新型外科手术使用非创伤性颅内监测方法，能够减少患结节硬化症(TSC)儿童癫痫发作频率。

在该研究中，New York大学医学中心(NYU, USA)的研究人员，进行了25例TSC患者手术切除结节的手术，中位数年龄为4岁。在NYU小组进行的第一阶段，放置了电极以鉴别原发性和继发性癫痫位点。在第二阶段，这些癫痫位点被切除。在第三阶段，在所有被发现的癫痫位点被切除之后再次植入电极。

22例患者接受了三个阶段的外科手术，3例接受了2个阶段的手术。13例患者放置了两侧电极，12例放置了单侧电极。在手术后6个月，21例儿童没用癫痫发作，只有1例出现非致残的部分发作。其余儿童包括两例癫痫发作减少了90%以上，2例减少了50%。因为是多位点癫痫发作，5例儿童中有4例开始并没用作为手术候选人，在多阶段手术后癫痫不再发作。这些结果发表在20065月的《儿科学》之上。

Multifocal Brain Surgery Reduces Epileptic Seizures
 
A new surgical approach using invasive intracranial monitoring can reduce seizure frequency in children with tuberous sclerosis complex (TSC), according to a new study.

In the study, conducted by researchers from New York University Medical Center (NYU, USA), 25 TSC patients with a median age of four years underwent surgical removal of the tubers. In the first stage of the approach developed by the NYU team, electrodes are placed to identify primary and secondary epileptic foci.

In the second stage, these foci are resected. With a third stage, electrodes are reimplanted after resection and any residual foci identified are resected. Twenty-two of the patients underwent a three-stage surgical approach and three had a two-stage approach. Thirteen of the patients had bilateral electrode placement and 12 had unilateral placement. At six months or longer following surgery, 21 of the children were seizure-free or had only non-disabling simple partial seizures. The remaining children included two who experienced a higher-than-90% drop in seizure frequency and two with a lower-than-50% reduction in frequency. Four of five children who were not originally considered candidates for surgery, due to multiple seizure foci, were rendered seizure-free with the multi-stage approach. The results were reported in the May 2006 issue of Pediatrics.