非小细胞肺癌动态CT 增强值与正电子发射计算机体层摄影脱氧葡萄糖标准摄取值的相关性探讨

丁其勇 滑炎卿 管一晖 赵军 朱凤 毛定飚 葛虓俊 张国桢
【摘要】 目的 探讨非小细胞肺癌动态CT 增强值与正电子发射计算机体层摄影( PET) 中
18 氟-脱氧葡萄糖( 18F-FDG) 标准摄取值( SUV) 的相关性。方法 搜集行PET-CT 和动态增强CT 检查
的28 例非小细胞肺癌和13 例良性肺结节病例, 测量结节增强前后各时相的平均CT 值、18 F-FDG 标
准摄取值的最大值和平均值, 计算结节增强峰值, 用Pea rson 相关分析方法评价良恶性结节动态CT
增强峰值和18 F-FDG SUV 的相关性。结果 非小细胞肺癌和良性结节CT 增强峰值[ ( 35. 09 ±
11. 41) 、( 26. 92 ±19. 98) HU] 的差异无统计学意义( t = 1. 374, P = 0. 189) , SUV 最大值( 7. 23 ±4. 38、
2. 97 ±2. 80) 差异有统计学意义( t = - 3. 972, P < 0. 001 ) , SUV 平均值差异有统计学意义( t =
- 4. 061, P < 0. 001) 。非小细胞肺癌CT 增强峰值[ ( 35. 09 ±11. 41) HU] 和18 F-FDG SUV 的平均值
( 4. 93 ±3. 53) 及最大值( 7. 23 ±4. 38) 之间均无相关关系( r = - 0. 040, P = 0. 839 及r = 0. 056, P =
0. 778) 。结论 非小细胞肺癌动态CT 增强值与FDG SUV 之间无相关关系, FDG SUV 可能不适用于
非小细胞肺癌抗肿瘤血管生成治疗的疗效评价。
【关键词】 肺肿瘤; 体层摄影术,X 线计算机; 体层摄影术, 发射型计算机; 氟脱氧葡萄糖F18
Corr elative investigation of dynamic contr ast CT a nd positr on emission tomogr aphy with
18-fluor odeoxy glucose standar dized uptake value in non -small cell lung cancer DING Qi-yong* ,
HUA Ya n-qing, GUAN Yi-hui, ZHAO Jun, ZHU Feng, MAO Ding-biao, GE Xia o-jun, ZHANG Guo-zhen.
* Department of Ra diology, Hua dong Hospital, Shanghai 200040, China
【Abstra ct 】 Object ive To explore the correlation of dynamic enhanced CT attenuation and
18-fluorodeoxy glucose ( 18 F-FDG ) standardized uptake value ( SUV) in non-small cell lung cancer
( NSCLC) . Met hods Twenty-eight NSCLC patients and 13 patients with benign nodules ( 28 male,
13 female; age range 15 - 79 years, median 57 years; the diameter range from 0. 8 - 4. 0 cm, mean
2. 2 cm) were examined on Siemens biograph sensation 16 PET-CT with 18F-FDG. Dynamic enhanced CT
scan was performed on Siemens sensation 16 PET-CT or 16 slice CT in 23 patients and other 18 patients had
the results of dynamic CT from other hospitals. The mean CT attenuation of ROI on precontrast and
postcontrast multi-phase images , the maxium and average SUV of 18 F-FDG were respectively measured. The
correlation between the peak attenuation( APA) and SUV was analyzed with pearson correlation coefficient
test. Result s The CT APA between NSCLC and benign nodules had no significance difference ( t = 1. 374,
P = 0. 189) . The difference of maximum and average SUV between NSCLC and benignity were significant
( t = - 3. 972, P < 0. 001 & t = - 4. 061, P < 0. 001 respectively) . No correlation was found among APA,
maximum SUV ( 7. 23 ±4. 38) , and average SUV( 4. 93 ±3. 53) ( r = - 0. 040, P = 0. 839 & r = 0. 056,
P = 0. 778) . Conclusion There is no correlation between APA and SUV in NSCLC. SUV is probably not
suitable for the evaluation of the effects of anti-angiogenesis therapy.
【Key words 】 Lung neoplasms; Tomography, X-ray computed; Tomography, emissioncomputed;
Fludeoxyglucose F18

非小细胞肺癌动态CT 增强值与正电子.rar